Three South Africa players are due to make their international debuts against Ireland in this Saturday's test match at Lansdowne Road.
Bevin Fortuin is named at full-back, with Jaco Pretorius and Francois Steyn starting on the wing.
Elsewhere, Brian Habana moves to the centre as expected, where he will partner John de Villiers, with Ricky Januarie and Andre Pretorius the half-back pairing.
In the forwards, hooker and captain John Smith is joined in the front row by Lawrence Sephaka and CJ van der Linde.
Johan Ackermann and Albert van den Berg make up the second row, with Danie Rossouw named at number six, Juan Smith at number seven and Pierre Spies at number eight.