Tottenham visit Liverpool this afternoon with both sides seeking to prove they are genuine contenders for the Premiership title.
It's a West London derby at Craven Cottage where Fulham welcome their wealthy neighbours Chelsea.
Charlton travel to Aston Villa, who are still unbeaten under new manager Martin O'Neill.
Wigan host struggling Watford, while Arsenal visit Sheffield United.
Manchester United travel to Reading hoping to take three points off the Premiership newboys, while Manchester City will be hoping for an upturn in fortunes as they welcome West Ham.
Middlesbrough host Blackburn, who are so far winless on their travels, while Arsenal welcome Sheffield United.