Number 10 has denied claims that Larry the Downing Street cat is disliked by the Cameron family.
Following allegations in a new book that the rescue pet was little more than a public relations prop, a "savelarry" hashtag quickly took off on Twitter.
Downing Street moved to dismiss suggestions in Matthew d'Ancona's In It Together that the cat was unloved.
A spokesman said: "Totally untrue. He is very popular with everyone in the building and we all get on purr-fectly well."
Larry was re-homed at Number 10 on February 15 2011 by animal charity Battersea Dogs And Cats Home.
But the cat's initially lackadaisical approach to his mousing duties led to speculation that his days at No 10 could be numbered.
In August last year Downing Street confirmed the six-year-old feline had finally recorded a kill.
Ladbrokes today gave Mr Cameron 1/2 odds of leaving Downing Street first with Larry the cat on 6/4.
Jessica Bridge of Ladbrokes said: "This is a new low for Cameron during his time as PM, and despite his dislike for the cat, we favour Larry to outlast him at Number 10."