The hive was stolen from a community garden in Marlpit Lane, Norwich, between December 13 and 22.
It contained bees hibernating for the winter. Hives are typically home to between 20,000 and 60,000 creatures.
A Norfolk Police spokesman said: "It would have taken two people to move the structure.
"Police are keen to hear from anyone who may have witnessed the incident or has information concerning the whereabouts of the stolen hive."
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