A drop in the use of cheques has been blamed on the loss of over 40 jobs in Lisburn.
Up to 46 workers at Communisis on Altona Road have been told the factory is to close and their jobs relocated to England.
The firm prints chequebooks for banks including Barclays and said the move was in response to a 50% fall in the number of people using cheques.
Staff have been given the option of transferring to Crewe, but Communisis' director of human resources, Tony Commons, said he appreciated that not many Northern Ireland workers would be able to relocate to England.
He added that the company - which also has bases in London, Leeds, Liverpool, Manchester, Bath and Bristol - is downsizing all its offices as the use of cheques wanes.
The Payments Council, a banking industry body, had been planning to replace cheques as a means of payment by 2018 but was forced to do a u-turn last year.
After widespread criticism from MPs and charities, the organisation said that cheques would be retained for "as long as customers need them".
The news follows more job losses at a training firm in Belfast earlier this week.
The Northern Ireland branch of the staff training company First4Skills in the city's Gasworks is to close with the loss of around 40 jobs.
The firm, which has around 600 staff across the UK, has gone into administration.
A spokesperson for the administrators, Deloitte, said branches in Wales will also close.
Parts of the company in Scotland and England have been sold on to new owners.