Manx2, the Isle of Man-based airline, has launched a new return route from George Best Belfast City Airport to London Oxford Airport.
The service, which began yesterday, will operate five days a week, with fares starting from £74.95 one-way including taxes.
London Oxford Airport is in Kidlington, Oxfordshire, 40 miles outside London.
David Buck, Manx2.com's managing director, said the new route was a welcome addition to existing services from the Isle of Man and Jersey to London Oxford Airport.
"It is another example of our commitment to delivering our passengers sensible and affordable travel through a first-class uncongested airport," he said.
Chris Orphanou, managing director of London Oxford Airport, said the launch of this new scheduled service gives the airport an opportunity to showcase its world-class facilities.
Brian Ambrose, chief executive of George Best Belfast City Airport welcomed the news.
"We're delighted that our long-standing partner airline Manx2.com is to broaden its route network," he said.
"I am sure London Oxford will prove an interesting destination for passengers and adds another London area airport to our rich UK route network and growing European portfolio."