Around 12 new jobs are to be created as a dental surgery in Carryduff plans another on Belfast's Lisburn Road.
NI Dental Care will form a subsidiary of Church Road Dental Care, founded by David Mann and Anne Higgins in 2009.
According to Mr Mann, the expansion of the business, supported by Danske Bank, has been driven by a growing demand for the practice's services in Carryduff over the past four years.
In addition to the new jobs, NI Dental Care will be offering a range of NHS treatments, as well as private treatments.
Mr Mann said that the Church Road Dental Care practice in Carryduff has grown from just three staff four years ago to almost 20.
"We have created several new dental, dental nursing and administrative roles and, as NI Dental Care continues to grow in the coming months, we would expect this to increase further," he said.
"We saw a real gap in the local market, with few dental practices offering NHS treatments in the South Belfast area and, although we will also offer private treatments, we are proud of our commitment to the NHS and will continue to offer this valuable service where we believe there will be sufficient demand."
Anne Higgins added that Danske Bank has played a crucial role in the business expansion.
"We pride ourselves on our forward-thinking approach to the running of our practice, having introduced innovative online booking systems and SMS or email-led communication systems for those patients wishing to avail of it," she said. "Danske Bank, likewise, is very much a technology-led bank and, as well as providing us with the financial support to expand the business, has helped us increase efficiencies in our business through its range of digital banking solutions."
Danske Bank's latest sectoral report has growth of around 1.8% in the healthcare sector next year.