Sixty new full and part-time jobs will be created next year when Lisburn's first hotel opens its doors.
Lisburn City Council has given the green light to a proposal for a £10m Premier Inn Hotel.
The 60-bedroom hotel, part of UK hotel group Whitbread, will be built at parkland on Hillsborough Road.
Des Taggart from Conway Group, which will be developing the site, said: " We're delighted to have achieved the final stage of planning and that we can now move on site to start work on this much-needed hotel for Lisburn.
"The hotel should be complete within 12 months and ready to open to the public in spring 2009."
The scheme includes a restaurant which is to be called Table Table.
Mark Adams, Whitbread Northern Ireland's acquisitions manager, said: " Lisburn is a city on the up and this site offers an excellent location.
"We're very excited to be bringing this new hotel to the area and are really looking forward to seeing the site develop and to welcoming our first guests."
Whitbread, the UK's largest hotel group, has 500 hotels and welcomes more than 10 million guests every year.
Lagan Valley DUP MP Jeffrey Donaldson has also welcomed the development.
"This investment from the UK's largest hotel group sends an excellent message about Lisburn and provides a much-needed tourism amenity for the city and the surrounding area," he said.
"I've met with the developers and the Whitbread representatives and know their commitment to this hotel and am looking forward to seeing what is hopefully the first of a number of hotels coming to Lisburn."