Juliette Binoche is to team up with Edgar Ramirez for romantic drama A Monkey On My Shoulder.
Both the Oscar-winning French star and rising Venezuelan actor would play surgeons in love, whose relationship is challenged by an unexpected pregnancy, a love triangle and a booze-fuelled and mad trip through the Amazon, reported Cineuropa.
Marion Laine will direct the film, which is based on Matthias Enard's book.
Filming is scheduled to start shortly, with a release set for 2012.
Juliette - who won a best actress Oscar for her performance in The English Patient - will next appear in US thriller The Son Of No One alongside Channing Tatum, followed by David Cronenberg's Cosmopolis opposite Robert Pattinson.
Having appeared in The Bourne Ultimatum and Che, Edgar will make his Hollywood debut in the Clash Of The Titans sequel, Wrath Of The Titans in March 2012.