George Clooney and Sandra Bullock's new film Gravity is set to open the 2013 Venice Film Festival.
Alfonso Cuaron's sci-fi thriller, starring the Hollywood A-listers as scientists lost in space, will have its world premiere in 3D on the opening night on August 28 at the Lido, following the opening ceremony.
The film is also screening out of competition at the festival.
The last time Venice opened with a science fiction movie was in 2000 with Clint Eastwood film Space Cowboys.
Alfonso's Spanish language drama Y Tu Mama Tambien, starring Gael Garcia Bernal and Diego Luna, won the Golden Osella for best screenplay and the Marcello Mastroianni Award in 2001, while Children Of Men - which starred Clive Owen and Julianne Moore - won the Golden Osella for best cinematography in 2006.
The Venice Film Festival, now in its 70th year, runs from August 28 to September 7.