Will Ferrell and John C Reilly are set to reunite for comedy Devil's Night.
The Step Brothers stars are said to be "attached" to take the lead roles in the Halloween-themed film, which has been written by Andrew Mogel and Jarrad Paul, reported The Wrap.
The pair would play former long-time best friends Leonard and Gabe, who decide to put their differences aside to save their neighbourhood from destruction, as the spooky holiday spirals out of control with mayhem and mischief.
Devil's Night, which will be produced by Will and Adam McKay's production company Gary Sanchez Productions and Sony, will mark the first time they have starred together since 2008's Step Brothers. They also starred together in 2006's Talladega Nights: The Ballad Of Ricky Bobby.
Both actors had uncredited roles in Tim And Eric's Billion Dollar Movie, and John is rumoured to make a guest appearance in the Anchorman sequel.
Step Brothers was a box office hit, grossing around 128 million dollars (£80 million) worldwide when it was released.
Will, who made an uncredited cameo in The Internship, will next reprise his role as newsreader Ron Burgundy in Anchorman 2: The Legend Continues, which will be out in December.
John, who voiced the lead role in Disney's Wreck-It Ralph, is filming Marvel's Guardians Of The Galaxy, where he plays Rhomann Dey, the leader of Nova Corps, alongside Glenn Close, Zoe Saldana and Benicio del Toro.
The 48-year-old will also star in zombie comedy Life After Beth, with Anna Kendrick and Dane DeHaan.