Drew Goddard is in talks to direct the Sinister Six film, from his own script.
The Cabin In The Woods filmmaker is said to be in discussions to take the reins on Sony's Spider-Man spin-off, reported Variety.
The 39-year-old has been collaborating with four other writers - Alex Kurtzman, Roberto Orci, Jeff Pinkner and Ed Solomon - on overseeing the story over several films, which will also include a movie about villain Venom.
The five writers, along with producers Avi Arad and Matt Tolmach and Amazing Spider-Man director Marc Webb, have formed a "franchise brain trust" to expand the comic-book universe for the brand, which is licensed from Marvel, and to develop a continuous tone and thread throughout the films.
Sony and Marvel Entertainment first revealed the Sinister Six and Venom projects in December, as part of Sony's move to expand Spidey's universe by bringing in more villains.
The Sinister Six super-villains, who first appeared in the comics in 1964, were drawn from Spider-Man's list of enemies. Led by Doctor Octopus, they included Electro, Kraven the Hunter, Mysterio, Sandman and the Vulture.
Topher Grace played Eddie Brock Jr/Venom in Sam Raimi's Spider-Man 3, while Sandman was portrayed by Flint Marko in the same film. Jamie Foxx plays Electro in the upcoming Amazing Spider-Man 2.
Alex, Roberto and Jeff are writing the screenplay for The Amazing Spider-Man 3, with Marc back on directing duties ahead of its release in June 2016.
The Amazing Spider-Man 4 has been scheduled for May 2018, while release dates for the Venom and Sinister Six sequels have not been unveiled.