The Prisoners actor is currently in talks about the lead role, which rapper Eminem was previously attached to, reported The Wrap.
Jake would play a left-handed fighter who wins a title but then suffers a tragedy. He then has to rebuild his life in order to win the respect of his daughter.
Southpaw will be directed by Antoine Fuqua and production is due to start next year.
Jake, 32, can soon be seen in erotic thriller Enemy and crime film Nightcrawler.
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Your dry humour will be very popular. It's always difficult bringing a large group of people together. Everybody feels like they are walking on eggshells. After cracking a few jokes, you'll put the group at ease. Resist the temptation to make fun of relatives, especially the more sensitive members of the group. Nobody likes feeling singled out. Watching a light hearted comedy can also be a great way to generate a festive atmosphere. This is a time when people can put their differences aside.More