Rhys Ifans and Lucy Punch are the latest additions to comedy Squirrels To The Nuts, according to reports.
The Help actress Ahna O'Reilly and Jake Hoffman have also joined the cast of Peter Bogdanovich's movie, said The Hollywood Reporter.
Welsh actor Rhys is to portray a film star, with comic actress Lucy as an Eastern European escort. Ahna has been cast as a reformed escort and Jake is to make a cameo as a hotel employee.
Owen Wilson is already on board to play a married Broadway director, who meets a call girl (played by Imogen Poots) and tries to convince her to change her life, "causing a domino effect that complicates his life".
Jennifer Aniston, Kathryn Hahn, Cybill Shepherd, Richard Lewis, Austin Pendleton and George Morfogen also make appearances in the comedy, which is being produced by Wes Anderson and Noah Baumbach among others.
Squirrels To The Nuts, due for release in 2014, marks Peter's return to film directing in 13 years, since period drama The Cat's Meow in 2001.
Rhys, who played The Lizard in The Amazing Spider-Man, is also starring in Serena alongside Jennifer Lawrence and Bradley Cooper, and has a small-screen role as Mycroft Holmes in Sherlock series Elementary.
Lucy, who starred in Woody Allen's You Will Meet A Tall Dark Stranger and comedy Bad Teacher, will next be seen in action comedy Cottage Country with Malin Akerman.