The X-Men actor beat competition from actors including Jack Huston and Toby Kebbell to win the coveted part, reported Deadline.
Scottish star James, 34, is currently negotiating his deal to star in director Paul McGuigan's film.
He will join former Harry Potter star Daniel Radcliffe, who has already signed up to play the character Igor.
Little is known about the new sci-fi take on Mary Shelley's classic tale, but Igor is thought to be a hunchback who assists Frankenstein in creating his monster.
COMMENT RULES: Comments that are judged to be defamatory, abusive or in bad taste are not acceptable and contributors who consistently fall below certain criteria will be permanently blacklisted. The moderator will not enter into debate with individual contributors and the moderator’s decision is final. It is Belfast Telegraph policy to close comments on court cases, tribunals and active legal investigations. We may also close comments on articles which are being targeted for abuse. Problems with commenting? firstname.lastname@example.org
Your home life is undergoing big changes. Youngsters may decide the time is right to fly the nest. An elderly relative may come to live with you. You might move in with a loving partner. Whatever form this new situation takes, it will be empowering. You'll get help that was previously unavailable. If your current home can't support the lifestyle changes in your household, it is time to move. Search for a quiet hideaway where you can all rest and relax after a hard day's work.More