Kristen Stewart will reportedly not star in her mum Jules' directorial debut.
The Twilight star had been rumoured to take the lead alongside Nikki Reed in the film, but following scheduling conflicts, her elder brother Cameron will now make his big-screen debut as a male prisoner instead, said Variety.
Beginners actor Goran Visnjic will play a record producer who finds himself in K-11 - the Los Angeles County Jail section reserved for homosexuals - after a three-day binge.
US actor DB Sweeney and Youth In Revolt's Portia Doubleday will also co-star in the drama.
Filming on K-11, which has been in development for more than two years, has already started.
Kristen, best known for playing Bella Swan in the Twilight Saga series, has been filming Rupert Sanders' fairytale remake Snow White And The Huntsman, where she portrays a feisty version of the princess.