Christopher Mintz-Plasse and Dave Franco are teaming up for Townies.
The duo, who have made a series of Funny Or Die videos together, are to share screen time in Nicholas Stoller's upcoming comedy, reported Deadline.
Seth Rogen and Zac Efron are already on board, with Rose Byrne in talks.
Seth has been cast as a man who can't stand living near a university fraternity. Zac is to play the club's president, with Dave confirmed to portray the group's vice president. Christopher is rumoured to have a role in the fraternity.
Christopher - who starred in Superbad and Kick-Ass - will next reprise his dual role as Chris D'Amico and Red Mist in Kick-Ass 2, and his voice part as Fishlegs Ingerman in the How To Train Your Dragon sequel.
Dave, the younger brother of actor James, will next be seen in magic thriller Now You See Me alongside Jesse Eisenberg, Mark Ruffalo and Morgan Freeman.