Matthew Modine and Martin Sheen are to lead the English-language dub of Wrinkles.
The pair will lend their voices to the English version of the animated feature from Spain, reported Variety.
George Coe will also voice a part in the new version, which is due out in 2014.
Wrinkles was adapted from a graphic novel by Paco Roca and directed by Ignacio Ferreras.
It is set in a retirement home and follows the friendship between wheeler-dealer Miguel and Emilio, who is suffering the first symptoms of Alzheimer's disease.
The film has already been a big hit in Spain.