Penny Smith will bow out of her GMTV job on Friday after 17 years on the sofa.
A spokesman for the ITV show confirmed there will be "surprises and old faces" in store for the 51-year-old throughout the show.
Smith joined the breakfast television show in April 1993 and has also written novels, produced yoga videos and shown what her singing skills have to offer on BBC reality show Just The Two Of Us.
GMTV is undergoing a revamp and there have been months of speculation over the future of its presenters.
Former The One Show host Adrian Chiles is joining the line-up as part of his new deal with ITV.
John Stapleton has been given a new role out and about covering breaking news stories as the show's first special correspondent.
Smith's post-GMTV projects include a BBC Radio 2 opera show and her third novel.
She said previously: "It's an ideal time for me to say goodbye to early mornings.
"Now that the format has changed, I have taken the plunge and am moving on."