David Thewlis and Brendan Gleeson are the latest additions to horror thriller Eliza Graves.
The two actors - who worked together on the Harry Potter films - have joined a cast that already includes Kate Beckinsale, Jim Sturgess, Sir Ben Kingsley and Sir Michael Caine, reported Deadline.
Directed by Brad Anderson, the film is based on a short story by Edgar Allen Poe, The System Of Doctor Tarr And Professor Fether. It is expected to start production in Bulgaria within the coming weeks.
Kate has been cast in the title role of a beautiful patient in a mental institution, who a young trainee doctor (played by Jim) falls in love, leading to a complicated relationship.
Joseph Gangemi has adapted Poe's story for the big screen for Millennium Films.
Mel Gibson is among the producers for the film.
David, who previously appeared in The Lady and War Horse, will next appear in Red 2 alongside Bruce Willis and Dame Helen Mirren, the WikiLeaks film The Fifth Estate with Benedict Cumberbatch and Terry Gilliam's drama The Zero Theorem.
Irish star Brendan will feature in The Smurfs 2 and Calvary alongside Chris O'Dowd.