Aretha Franklin has cancelled all concert dates and personal appearances until May.
A spokeswoman for the 68-year-old Queen of Soul said the singer's doctors "have required her to do so".
The news came several days after publicist Tracey Jordan announced that Franklin had been discharged from a Detroit hospital following a brief stay.
Ms Jordan refused to say whether the events were connected and did not offer any details about Franklin's condition.
One of the shows being cancelled is a Christmas concert scheduled for Detroit's Fox Theatre on December 9.
Theatre operator Olympia Entertainment said the show was being called off "due to medical reasons".