Frank Skinner and Jimmy Carr face being torn off a strip on live TV - by being waxed as a charity forfeit.
Also aiming to avoid the painful punishment are Stephen Fry and Al Murray in a stunt for Comic Relief.
Each of the funnymen has been honoured with a new flavour of Walkers crisps which are being sold to raise £1 million for the charity.
The biggest-selling star will avoid the punishment but the three others will be subject to a hair-erasing moment at the hands of Denise Van Outen.
She will wax them on TV for Red Nose Day on March 18.
Frank, whose flavour is Frank Roast Dinner, said: "The big upside of this is that Walkers will give five pence for every bag sold to Comic Relief. So even though, inevitably, three of us will suffer horribly, we will change lives."
He added: "The terrible forfeit is something that perhaps a lot of people would think would be brilliant.
"It involves Denise Van Outen in a very, very short, slightly starched, white clinical uniform, and you think 'Oh great', because she's a very attractive woman, but she will be waxing the victims.
"So it's nice to meet Denise Van Outen, but not when she's actually incurring quite a lot of physical pain on you."
Stephen is championing the Stephen Fry Up while Jimmy has the Jimmy Con Carrne flavour and Al has a Steak And Al Pie variety.