A tweet from the band's official account said "we have now come to the end of our incredible time together".
The message was sent shortly after the five singers came off stage in Liverpool, marking their last performance together as a group.
The TV manufactured band reunited for the 12-date UK tour after spending three years on solo projects.
The tweet said: "Dear Alouders, we just want to say from the bottom of our hearts Thank you!!
"This tour has been an amazing experience and the perfect chance to say thank you for being on this journey with us through a decade. It has far exceeded any of our dreams and we hope we are forever your inspiration and reminder that dreams really do glitter!! Your love and support will stay with us forever but we have now come to the end of our incredible time together. Love you lots."
The band had previously hinted at an imminent split after confessing they had no plans together after the end of the tour. At a press conference to announce the Ten Tour last year Cheryl Cole said "we haven't actually made any plans further than the tour" before adding that they would "wait and see how the fans react" before deciding what to do next.
Cheryl, Nicola Roberts, Kimberley Walsh, Nadine Coyle and Sarah Harding were put together by the ITV show Popstars: The Rivals in 2002 and claimed their first number one with Sound Of The Underground.
Looking back on their decade together, Cheryl tweeted on Wednesday night: "To the people that haven't been able to make it, for what ever reason, we feel your support regardless and have done for 10 yrs."
Nadine also tweeted before going on stage: "I have seen many of you at the tour work as hard as us! That is why I cried last night on stage & probably tonight again. Not sad, happy. Happy tears. I cannot thank you enough. I love seeing all your faces. Ok more tears. I love you all forever. Xxxxx NC."
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