Katie Price and Alex Reid are favourites to split up in 2011, it has been reported.
Bookmakers William Hill have released their bets for the upcoming year and have started to see money for the reality TV couple to break up, with odds cut from 5/2 to 7/4.
"Our punters seem quite convinced that Katie and Alex are on the rocky road to ruin - it seems as though the only way that this bet will be a loser is if they do not actually make it to 2011," said spokesman Joe Crilly.
Justin Timberlake and Jessica Biel's relationship is also tipped to hit the rocks, with odds of 5/1, followed by Demi Moore and Ashton Kutcher and Vernon Kay and Tess Daly, at 6/1 each.
Strictly Come Dancing champs and rumoured new lovers Kara Tointon and Artem Chigvintsev have been given odds of 8/1, while Lewis Hamilton and Nicole Scherzinger are at 10/1, with 3/1 odds that they will tie the knot.
Prince William and Kate Middleton, who are set to marry on April 29, have been given odds to split of 66/1, the same as David and Victoria Beckham and new parents Sir Elton John and David Furnish.
The bookies' other favourites include Colin Firth to win the best actor Oscar for The King's Speech at odds of 1/3, Simon Cowell to be knighted (1/3), and The X Factor's Wagner to have a No 1 single (8/1).
Bizarre bets include Lady Gaga's Grammy gown being made of vegetables (4/1), Simon Cowell to be the next Bond (100/1) and Stephen Fry to play the next Doctor Who (50/1).