Seth MacFarlane is too busy to host the Oscars in 2014, he said.
The multi-talented comedian said on Twitter that he "tried to make it work schedule-wise, but I need sleep".
Seth said in his tweet that Academy Awards producers Craig Zadan and Neil Meron are among the best in the business.
Zadan and Meron produced this year's Oscars show, which earned higher ratings among coveted younger viewers, and will be returning for the 2014 telecast.
Seth earned mixed reviews for his first outing as Oscars host in February, with some finding his material sexist and anti-Semitic.
The creator of Family Guy suggested Oscars producers tap eccentric actor Joaquin Phoenix to host the show.