The BBC is aiming to undertake the largest ever health-screening session for a new TV special which will look at the extent of undiagnosed diseases.
It aims to take 1,000 people and look at the hidden health problems they may have for a two-part BBC1 show Long Live Britain, in an effort to help people transform their lives.
TV stars Crissy Rock and Jodie Prenger have also agreed to be be tested for the programmes which will look at the way the country approaches three of Britain's biggest preventable diseases.
Jodie said: "I wanted to take part in the programme because knowledge is power. I was really scared about facing up to my health but with my family's history of type 2 diabetes, I didn't want to bury my head in the sand anymore.
"I didn't want to wait until it was too late and I was backed into a corner without any choices."
Between them, type 2 diabetes, cardiovascular disease and liver disease kill 200,000 people each year and are estimated to affect around 11 million people.
Experts and 50 NHS volunteers will take on the challenge this Saturday at the Rugby Football League's Magic Weekend in Manchester with sport fans and local people being tested. Three leading charities - Diabetes UK, Heart UK and the British Liver Trust - along with NHS staff will advise those identified as being at risk how they can limit the impact on their health and change their lives.
Another well-known face from TV and film, Ricky Grover, will be taking part and said: "I'm at that stage in my life where I knew I needed to get a proper health MOT. I knew I needed to lose weight and my problem like a lot of people, is that I lack motivation."
The programmes are to be screened early in the summer.