Patricia Arquette has filed for divorce from fellow actor Thomas Jane in Los Angeles, court records show.
The Medium actress cited irreconcilable differences as the reason for the break-up in a divorce petition filed on Friday.
It's the second time Patricia has sought to end her marriage with Thomas, who now stars in the HBO series Hung.
She moved to dismiss her previous filing in July 2009.
Arquette, an Emmy Award-winner, is seeking legal and physical custody of the couple's seven-year-old daughter.
The couple were married in May 2006. Court filings did not indicate when they separated.