This Life stars Jack Davenport and Natasha Little are to be reunited on screen in new ITV medical drama Breathless.
The pair first appeared together in the popular 1990s BBC series, which followed the lives of a group of twenty-something professionals, and ran for two series.
Upcoming period drama Breathless is set in a London hospital in 1961 and is based around a group of doctors and nurses as the UK was on the brink of cultural change.
Jack had already been announced to play surgeon Otto Powell, but will now be joined by newly-cast Natasha who will play his wife Elizabeth. Their perfect-looking marriage hides a "devastating secret", according to ITV.
In This Life viewers saw Jack's character, smarmy charmer Miles, make advances on fellow lawyer Rachel (played by Natasha).
Although the main cast reunited 10 years later in 2007 for a one-off special This Life + 10, Natasha was not involved.
Jack has gone on to achieve US success, and starred in the Pirates Of The Caribbean blockbuster films and Smash, while Natasha has appeared in acclaimed dramas such as Vanity Fair and Mistresses.
Also added to the cast are Gavin And Stacey actress Joanna Page, Sarah Parish from Cutting It and Iain Glen who stars in Game Of Thrones.
Filming has already begun in London.