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Trust your gut instinct to tell you something's wrong with your tummy

Published 19/01/2016

Balancing act: ‘good bacteria’ can help our stomachs stay healthy
Balancing act: ‘good bacteria’ can help our stomachs stay healthy
Charity work: Chloe O’Neill
Diet control: Lauren Anderson
Weight loss: Gary Donaldson

Digestive disorders are on the rise with the condition of our insides turning into a First World crisis. But what exactly is causing it, asks Siobhan Norton.

No man is an island, they say. But even the biggest recluses among us are never alone - we are all, in fact, outnumbered.

From the moment we are born, our bodies are colonised by other organisms - a vast population of microbes setting up home on our skin, inside our mouths and noses, and in our gut. So much so that only 10% of the cells in our body are human cells.

It should come as no surprise then, that how our bodies work is less of a dictatorship and more of a democracy.

All the bacteria living within our body have to co-operate to help things run smoothly and prevent civil war.

This isn't for free, of course. We feed the hungry little blighters - and in return they help to break down our food and convert it to energy, provide essential enzymes and vitamins, and regulate our immune system.

The problems arise when the wrong kind of food helps the troublemakers to flourish at the expense of our healthy, helpful "good bacteria".

So far, so yoghurt commercial. But scientists now say that the microbiome - the collected micro-organisms - in our digestive system is more than a mulching factory for food, but in fact the "second brain" - which may be just as important as the first brain in our heads.

Perhaps we already know this to some extent - we associate the gut with raw, instinctive emotions and reactions. Gut reactions, even.

We know that if we're stressed or anxious, this will be the first place we show symptoms of it, which makes sense. In times of fight or flight, the body will shut down its energy-sapping digestive processes to allow the energy to be diverted elsewhere.

A persistent problem nowadays, experts reason, is that we are in a constant state of stress or anxiety, so our gut never gets the chance to do its job properly.

A 2011 study in Brain, Behaviour and Immunity suggested that stress alters the structure of the microbiome. A 2012 study indicated that, in turn, gut bacteria can affect our stress responses.

There is no denying that some very modern maladies are on the increase.

Irritable bowel syndrome, that spectrum of general digestive unpleasantness, afflicts an estimated 10 to 20% of the UK population.

More serious, perhaps, are the inflammatory bowel diseases like Crohn's and ulcerative colitis.

A 2012 study published in the journal Gastroenterology indicated that inflammatory bowel diseases (IBDs) are emerging as a global problem. Incidences are far higher in Europe and North America - although there is considerably less data from developing countries.

Autoimmune diseases such as lupus, coeliac disease and type 1 diabetes are also on the rise. Between 2001 and 2009, the incidence of type 1 diabetes increased by 23%, according to the American Diabetes Association. And, of course, there's the number one Western problem - obesity.

Why, then, is there such a growth in certain diseases in the West? Some say that we are quite literally navel-gazing - a poor man working on a factory line in Hanoi has little time to moan about an upset tummy.

Or is our diet - high in sugar, processed foods and artificial ingredients, while being refined and low in fibre - causing serious damage to the delicate symbiosis of our microbiome?

One emerging theory behind the imbalance is the hygiene hypothesis. This goes straight back to - you guessed it - our gut. We are exposed to bugs from the second we are born, quite literally, as our first brush with bacteria will be from the mother as we emerge from the birth canal. Studies suggest that children born by Caesarean section don't get this initial burst of bacteria, and may have a weakened immune system as a result.

Similarly, as children grow up, they get dirty, put things in their mouth, kiss the dog, and essentially do lots of things to expose themselves to bacteria. But when we get trigger-happy with the Dettol and load up on unnecessary antibiotics, there is far less exposure. Of course, hygiene is good, and antibiotics have prevented far more diseases and premature deaths than they could cause.

But our immune systems could be so coddled that they can't withstand the first threat of real infection.

Professor Tim Spector believes that most of the microbes in our systems are crucial for good health, but that our modern lifestyles have upset the balance. "We start life with a weakened biodiversity," he says. "The tendency towards Caesarean sections, overclean environments, reliance on antibiotics, lack of fibre and a less diverse diet all contribute to a deranged microbiome."

In his book The Diet Myth: The Real Science Behind What We Eat, Spector looks beyond calorie-counting to how the food we ingest is really fuelling us, and how our gut bacteria could be influencing that - and vice versa.

He conducted an experiment with the help of his son, Tom - their mini version of the documentary Super Size Me. Tom lived off a diet of McDonald's for 10 days, giving a stool sample before and after. In the short time period, the junk food had dramatically reduced the diversity of his microbiome by 40%, and replaced "good" bacteria with those that can cause inflammation.

Dr David Perlmutter is another champion of the "gut brain" - and believes an imbalanced microbiome could be causing everything from Alzheimer's to autism. He has worked with patients suffering from various conditions, including Tourette's and multiple sclerosis, and claims they have seen dramatic improvements with an altered diet or procedures such as faecal transplants.

"Some of my most remarkable case studies involve people changing their lives and health for the better through simple brain-making edits to their dietary choices," he writes in his book, Brain Maker.

"They cut carbs and add healthy fats, especially cholesterol - a key player in brain and psychological health. I've watched this fundamental dietary shift single-handedly extinguish depression and all of its kissing cousins, from chronic anxiety to poor memory and even ADHD."

Spector is slightly more cautious. "We are making real progress, but people don't realise how young this field is," he says. "When it comes to illness, we need much more research to discover whether a disordered microbiome is causing problems or simply making them worse.

"For instance, autistic children have abnormal microbiomes, but they also tend to have abnormal diets."

It is certainly a complex area to study - a handful of soil contains more microbes than there are stars in the sky, Spector says, and our bodies contain 100 trillion of them, weighing more than four pounds in our guts alone. However, he says that he can tell if someone is healthy simply by examining their microbiome - and he has examined plenty.

He is part of the British Gut Project, the UK arm of the American crowdfunding effort to get a major sample of the population's bacteria. The project has been appealing to the public for donations - monetary and faecal - to help them gain more understanding of the geographical, dietary and genetic differences in people. In return for a donation, participants get a breakdown of their microbiome, but no dietary or medical advice is given on the back of it.

It may seem like an impossible quest - Spector admits we are sensitive about poo - but the project has been attracting about 100 volunteers a month, with 1,300 participants to date, to go with more than 3,000 in the US.

Spector believes that in the future a better understanding of the microbiome could lead to personalised diet advice. "Some people can eat meat without any ill-effects. Some people react differently to pasta, or lentils. There is even a 'skinny bacteria' - there have been tests on mice involving Christensenella. When the bacteria was transplanted into their microbiome they gained less weight."

Perhaps, then, the ultimate question is how to maintain a balanced microbiome. In his book, Perlmutter outlines his ideal diet to boost bacteria. It is rich in probiotic fermented foods like kimchi and sauerkraut, unprocessed meat and vegetables and (the good news) dark chocolate and red wine. Spector follows a similar regime. "I have cut out all processed foods - but have more coffee and dark chocolate." He says we need to think of our microbiome like a garden - we need to nourish the soil (intestines) for healthy plants (bacteria), while minimising weeds (disease-causing microbes).

"It's important to remember that you are never dining alone - you are with your microbes."

  • For further information, visit http://www.theibsnetwork.org/ or https://www.facebook.com/Crohns-and-Colitis-UK-Northern-Ireland-Group-101286756650211/?fref=ts

'I was in a lot of pain and it just wouldn't go away'

Chloe O'Neill (16) is currently  studying for her AS-levels and lives in Strabane. She says:

When I was 14, I was diagnosed with Crohn's Disease. It started with my eyes - they suddenly got sore and irritated and the doctor told me I had conjunctivitis.

The next time I went to the doctor, I was complaining of a sore tummy and always going to the toilet and feeling tired all the time. It wasn't until I went to the doctor to complain about my eyes and my tummy about the same time that they realised something was wrong.

Firstly I was diagnosed with ulcerative colitis and I had surgery to get an ileostomy bag fitted - waste products from my small bowel are diverted into an external bag instead of to my large bowel.

After the surgery though I felt so much worse. I was in a lot of pain and it just wouldn't go away. The hospital told me it was just post-operative pain, but it started to get worse and worse.

I eventually saw my surgeon who realised something wasn't right. I had more tests until eventually they realised that it was Crohn's Disease.

Crohn's Disease is a condition which simply gets managed with medication - it's trial and error until they find something that works because everyone is different. What works for me won't work for others.

At the moment I'm on a diet that's low on fibre, but high on calories so I can't eat lots of fruit and vegetables and I love them. I get flare-ups now and again and they're normally caused by stress.

A lot of people don't know anything about Crohn's so I got involved in Crohn's and Colitis UK. People think that an ileostomy bag sounds disgusting, but having it has enabled me to do a lot more than I could before. I don't need to make sure I'm near a toilet all the time for a start. Previously, I wasn't able to leave the house."

'I'm going to be on medication the rest of my life'

Lauren Anderson (22), from  Portadown, is studying politics at Ulster University. She says:

I have Crohn's Disease and I was diagnosed when I was 13. I started getting symptoms when I was on holiday in America and thought it was just a bug. About a month later it got really bad with a lot of pain and I couldn't stop throwing up, so my mum took me into hospital.

Because most of the pain was centred around my right side, the doctors thought I had appendicitis and scheduled me for keyhole surgery to have my appendix removed. It wasn't until they opened me up that they realised it was something else - while I was in surgery the doctors did a biopsy on my bowel.

I don't remember being told I had Crohn's Disease, as the doctors told my parents first and initially thought I had some kind of cancer.

As my family learned more about the condition, though, they realised that a lot of people they knew had it, too.

For the next couple of years I was in and out of hospital having tests. I had to take steroids and put on weight, going from a size 10 to a size 16, and it really knocked my confidence.

Eventually I had surgery to reconstruct my bowel when I was 15.

The surgery did help, though, and I wasn't in pain any more, but I still have Crohn's and I still have symptoms. I'll be on medication for the rest of my life and I still get flare-ups, usually triggered by stress. I try to control my diet and I don't have dairy any more.

It can be embarrassing, because people don't understand Crohn's and they wonder why I need to go to the loo all the time. However, I want to explain it to them in a bid to increase awareness.

I'm very lucky in that I've had a huge amount of support from my family and friends."

 'I thought my Crohn's Disease was really cancer'

Gary Donaldson (26) is a retail worker from Belfast. He says:

Just after my 18th birthday I was diagnosed with Crohn's Disease, but I'd been having symptoms for six or seven years before that. My doctor attributed my symptoms to anorexia as I had lost a lot of weight very quickly.

By the time I was diagnosed I had convinced myself I had cancer, so it was a real relief to find out what was actually wrong with me.

A year later I had a complete bowel resection because it was in pretty bad shape. I had to take a year out and resit my A-levels a year later. Despite this, though, I was able to go on to university and get a degree in forensic science.

I had five good years after the surgery, but I have been getting flare-ups recently so I've been working with doctors to find the right kind of medication.

Because of my experience I'm now very involved with Crohn's and Colitis UK's group in Northern Ireland where I work with young people. I can put them in touch with groups which can help as well as organise away days.

It makes a real difference once you've been diagnosed with a condition that not many people know much about to find others who have been suffering from the same thing."

Belfast Telegraph

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