As many as 10% of Britain's motorways and A-roads present an unacceptably high risk to drivers, a major report has revealed.
Half of all crashes occur on just one tenth of Britain's road network, the report from the Road Safety Foundation found.
Most of the higher-risk roads are in north-west England, Yorkshire and the Humber and the East Midlands, while Scotland has the highest risk rating of all the regions.
The West Midlands is the safest region, while the most persistently dangerous road is the A573 between Macclesfield in Cheshire and Buxton in Derbyshire.
The report, which covers 28,000 miles of roads, also found that one third of all fatal and serious crashes occur at junctions and that single carriageways offer six times the risk of danger to motorists than motorways and twice that of dual carriageways.
Drivers were seven times more at risk on major roads than on minor ones, the report said.
The report said the A573 which runs through the Peak District has severe bends, steep falls from the carriageway and is edged by dry-stone walls or rock face for almost all its length.
It is popular with tourists, heavy goods vehicles and high-powered leisure motorcyclists. Fatal and serious collisions on this section rose by 127% in three years - from 15 in the period 2003-2005 to 34 in 2006-2008, with most crashes at weekends during the summer in dry, daylight conditions.
Police records show that the vast majority of casualties were motorcyclists, from outside the local area, male, and with an average age of 35.
Three other roads in the Derbyshire area are listed in the persistently higher-risk road top 10 - the A5012 from the A515 near Pikehall to the A6 at Matlock; the A54 from Congleton to Buxton; and the A5004 from the A6 at Whaley Bridge to Buxton.