Kunis, who has appeared in Black Swan and Friends With Benefits, took the top place in the annual FHM 100 Sexiest Women in the World poll.
Her win brings to an end a four-year run of British stars at the top of the list. The top Brit this year is former Coronation Street actress Helen Flanagan, who finished in third place, while another face from Weatherfield, Michelle Keegan, came fourth.
Flanagan -- who took part in last year's I'm A Celebrity and was forced to undergo a series of bushtucker trials -- said: "It's a lovely confidence boost, especially when there are so many beautiful girls out there."
Tulisa Contostavlos, who saw her debut solo album flop and is thought not to be returning to The X Factor, plunged to number 11 following her win last year.
Singer Rihanna takes the runner-up spot, rising one place from her 2012 result.
Kelly Brook -- who topped the poll in 2005 but was down to number 20 last year -- has bounced back to fifth position.
The top 20 are:
1 Mila Kunis 2 Rihanna 3 Helen Flanagan 4 Michelle Keegan 5 Kelly Brook 6 Kaley Cuoco 7 Pixie Lott 8 Kate Upton 9 Cheryl Cole 10 Georgia Salpa 11 Tulisa 12 Taylor Swift 13 Jorgie Porter 14 Rosie Jones 15 Rita Ora 16 Katy Perry 17 Megan Fox 18 Mollie King 19 Beyonce 20 Jennifer Lawrence
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