Alzheimer’s wonder drug: it’ll be years before we get it

By Chris Thornton
Thursday, 31 July 2008

A new drug hailed as a potential breakthrough in the fight against Alzheimer's is still years away from being available in Northern Ireland, an MP whose husband suffers from the disease has said.

Lady Sylvia Hermon said revelations this week about the drug Rember — which has slowed the disease remarkably in a clinical trial — are "truly encouraging".

But, she said, "the major prize" of preventing the killer disease is still elusive.

Lady Sylvia has spoken movingly of the battle her husband, former RUC Chief Constable Sir John Hermon, has fought against what she describes as "a dreadfully cruel disease" since 2002.

Scientists at the University of Aberdeen announced earlier this week that they have developed a drug to slow down Alzheimer's.

Rember is the first drug to target protein "tangles" that kill brain cells.

A clinical trial involving more than 300 people using varying doses of the drug showed that progress of the disease was 81% slower in some patients.

Currently available drugs — there are three used by the NHS — slow the development of the disease, but not in every patient.

The Scottish team behind Rember, working with a Singapore drug company, is seeking cash for further trials and any approval for use in the NHS is still years away, after assessment by the National Institute of Health and Clinical Excellence (NICE).

"Any new positive development in the treatment of Alzheimer's disease is always welcome for sufferers, their families and other carers," Lady Sylvia said yesterday.

"However, the earliest this new drug could be available is likely to be in four years' time and, even then, its use in the NHS will be conditional upon NICE approval.

"So, while initial trials of this new drug are truly encouraging, especially in the treatment of early stage Alzheimer's, the major prize still remains in preventing this awful disease from developing in the first place."

An estimated 26 million people have Alzheimer's worldwide, and the numbers are growing as people live longer.

About 700,000 suffer from dementia in the UK, with about half diagnosed as having Alzheimer's.

Prof Clive Ballard, the Alzheimer's Society director of research, said the Rember announcement is "a major new development in the fight against dementia".

"It is the first realistic evidence that a new drug can slow cognition decline in people with Alzheimer's, by targeting the protein tangles that cause brain cell death," he said.

"This first modestly sized trial in humans is potentially exciting. It suggests the drug could be over twice as effective as any treatment that is currently available.

"However, we are not there yet. Larger scale trials are now needed to confirm the safety of this drug and establish how far it could benefit the thousands of people living with this devastating disease."

I think we all have the same question: where do i sign up for the trials. My husband is 65 and in early stages of this disease. We would even like to know where we can contribute to this fund. anyone with some answers please do so

Thank and God bless you

JoLynn Dougherty

Posted by JoLynn Dougherty | 09.02.09, 17:46 GMT

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Gentlemen you say larger trials are needed to confirm the safety of the drug. My question is how safe is it to have alzheimers continue unchecked without the drug? Lets keep things in perspective, people with Alzhimers are on deaths door, you may have the tool to change that! Surely it cannot make it worse. Make your trial worldwide!
Respectfully Submitted
Larry C.

Posted by Larry | 05.08.08, 15:24 GMT

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Its wonderful that finally a breakthrough has been made. My heartful congradulations to the people at Aberdeen for there hard work. Its to bad that my wife might never benifit from there discovery. I wish that the drug could be given out with a informed risk consent. If only I could stop the advance of the memory loss and bye time to find a cure

Posted by Bob | 01.08.08, 17:50 GMT

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Its amazing that the hard working team in Aberdeen have developed the drug when Governments around the world have vertually washed their hands about finding a cure, I only hope NICE can remove their heads from where the sun wont shine and realise the relief a cure can give both the sufferer and their carers

Posted by Richard Strudwick | 01.08.08, 08:57 GMT

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I think you may find the media build up the hopes in the headline and dash them in the last line. Scientists are not responsible for the marketing and NHS admin.

Posted by ron Todd | 01.08.08, 07:07 GMT

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Its wonderful news but why oh why do these scientists announce these things and build up the hopes of sufferers only to tell them that it will be years before they can be administered.

Posted by David McIlwaine | 31.07.08, 18:56 GMT

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hope this a breakthrough drug for Alzheimers patients.My mother has this cruel,crippling disease and although it will be too late for her hopefully for the future it will help other suffers.

Posted by dorothy bond | 31.07.08, 18:44 GMT

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My heartfelt thanks go to the hardworking team in Aberdeen also my heartiest CONGRATULATIONS.

Posted by audrey cossey | 31.07.08, 12:47 GMT

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