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Blood pressure drug ‘erases bad memories’

Monday, 16 February 2009

Memories can be erased using a drug commonly prescribed for high blood pressure, research has shown.

The discovery could lead to new ways of treating people suffering from the emotional after effects of traumatic experiences such as terrorist attacks or natural disasters.

But one British expert questioned the ethics of meddling with a person’s mind in this way.

Previous research on animals had shown fear memories are susceptible to being altered at the time they are recalled.

At this crucial stage the memories are “reconsolidated” in the brain. Studies suggested beta-blockers, a family of drugs normally used to treat high blood pressure, may interfere with the reconsolidation process.

A team of Dutch researchers artificially created a fearful memory by associating pictures of spiders with a mild electric shock delivered to the wrists of the 60 participants.

When the volunteers were shown the spider pictures 24 hours later their “startle” response — a measure of fear — was assessed by testing eyeblink reactions.

Administering the beta-blocker drug propranolol before reactivation of the fearful memory led to a marked reduction in the startle response.

After taking the drug, volunteers were much less disturbed by the spider pictures.

The findings, reported today in the journal Nature Neuroscience, raise the possibility of a new approach to tackling emotional problems and post-traumatic stress disorder.

Study leader Professor Merel Kindt and colleagues from the University of Amsterdam wrote: “Our findings may have important implications for the understanding and treatment of persistent and self-perpetuating memories in individuals suffering from emotional disorders.”

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I was on beta-blockers to treat familiar tremors from 1978 -1986. During that time, it seemed that I was a different person -practically fearless. Almost every memory prior to taking Inderal is gone –my childhood, my marriages, and raising my children.

Sadly, it seems that it not only wipes out the bad memories, but all the good ones as well. It is as though there was never any bonding with my parents or my children.

They are addictive and when doctors switched dosage to long acting I have severe –almost psychotic side effects to the point I had to be hospitalized and weaned off them.

Posted by Glenda Wilson | 20.02.09, 05:48 GMT

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This is ludicrous. It is highly unlikely that a drug will ever be developed that can SELECTIVELY erase memories that we choose to erase. Even to erase all "bad" memories would be very harmful as in many cases those memories would form the basis of many of our fundamental learnings / experiences. For example, if I have no memory of the time I burned my hand on a cooker, I am more likely to burn my hand again.

It is our experiences and therefore our memories that make us who we are.

Posted by Richard | 19.02.09, 15:53 GMT

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Is it really that the beta-blockers erased/subdued the memory? Could it be that the propranolol dispensed merely dulled the nervous system? While an interesting advancement (similar to the movie The Eternal Sunshine of The Spotless Mind), there are more serious scientific investigations to be carried out. The moral/ethical side of things should also be greatly considered - who sets the parameters for what is considered a "bad" memory for example?

Posted by No1 Fan | 16.02.09, 14:00 GMT

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