Belfast Telegraph

Tuesday 6 October 2015

Scientists crack secret of superbug’s resistance

Published 29/04/2011

A superbug's resistance secret has been uncovered by scientists, paving the way for new drugs to fight infections.

For the first time, researchers have discovered how a key protein helps MRSA (methicillin resistant Staphylococcus aureus) bacteria to evade antibiotics. The research is published today in the journal Science.

The Cfr protein acts on the ribosome, a molecular “factory” in cells responsible for making proteins that are vital for survival.

Many antibiotics bind on the ribosome in bacteria and stop it functioning, causing the bugs to die.

Through a chemical process called methylation, Cfr blocks the binding of antibiotics to the ribosome. At the same time it helps to keep the machinery working.

In the case of MRSA, the introduction of Cfr makes the superbug resistant to seven classes of antibiotics.

Cfr is made by a mobile gene that can move easily between different species of bacteria.

Scientists found that it passed from Staphylococcus sciuri, which normally only infects animals, to the human bug Staphylococcus aureus.

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