The grandmother of missing Madeleine McCann last night claimed that the four-year-old was drugged by whoever abducted her in Portugal.
Eileen McCann, originally from St Johnston, Co Donegal, said that, otherwise, her granddaughter would have screamed the family's holiday apartment down.
The 69-year-old's comments came 150 days since Madeleine vanished from the pretty Algarve resort of Praia da Lux.
No formal events were planned yesterday by her parents, Gerry and Kate, both 39, who marked the occasion quietly - still waiting for some indication of her whereabouts.
And Gerry simply told friends: "It is just another day without Madeleine."
Madeleine's grandmother, who now lives in Scotland, said that the family have been "going through hell" since the little girl's disappearance.
"I really believe they (whoever took her) gave her a drug. There is no way they carried her out of there without her wakening," she told the Sunday Mirror.
"If she was taken when she was sleeping by somebody she did not know she would have screamed the place down."
Mrs McCann also condemned ongoing suggestions that her son Gerry and daughter-in-law Kate were connected to Madeleine's disappearance.
"My son and Kate would never even slap their child, never mind do anything to harm her," she said. "They are running away from nobody because they are innocent."
She also slammed the Portuguese investigation, as well as rubbishing claims that DNA evidence found in the car hired by Madeleine's parents after she vanished proved her body had been in the vehicle.
"The thing is that little Amelie is wearing Madeleine's sandals and she is in and out of the car," she said.
"Cuddly toys are in it. Madeleine's toys are in it. Madeleine's tops are in it that Amelie is wearing. It's nonsense."
Mrs McCann praised the wonderful support she and the family have received from the people of Ireland - especially people from where she was born.
"We always keep in touch and we are always there for each other," she said, adding that local people knew her family would not be involved in Madeleine's disappearance.