Lisa was last seen at her home address in the Drumquin area of County Tyrone on Monday at 10.30pm.
She is described as 6ft tall, slim to medium build, with auburn short hair and wears glasses, which are red and silver in colour.
Lisa may have been wearing a light green hoodie-type top.
Lisa, or anyone who knows of her whereabouts, is asked to contact her family or police on 0845 600 8000.
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