An extra seven million US dollars (£4.5 million) has been earmarked for cystic fibrosis research and development.
A partnership between the UK, US and Ireland has been revealed in America.
It followed agreement among the governments that will allow scientists to collaborate on new areas of research.
First Minister Peter Robinson said: "This ongoing commitment to research collaboration with the US administration is a strong reflection of the close relationship between leading academics and the strategic importance of our ongoing relationship with the United States."
He said the agreement included new research areas telecommunications and energy/sustainability.
Deputy First Minister Martin McGuinness said: "I am delighted to announce funding of almost seven million dollars for a cystic fibrosis research project.
"This is the largest project supported to date through the partnership and it is of great importance for healthcare globally."
Employment and Learning Minister Sir Reg Empey said his department had already invested in nanotechnology.
"In Northern Ireland, I believe we are extremely well placed to continue to make a strong contribution to the success of this strategically important international initiative through our two research intensive universities," he said.