A leading pharmaceutical and medical devices firm is to cut 200 jobs.
Abbott is to lay off the workers at its Clonmel manufacturing plant after a downturn in demand for its older products.
A spokeswoman said the company was seeking the redundancies on a voluntary basis.
"The demand for our older products is declining and with that then we do not have the same need for the labour force," she said.
Several dozen staff who work on a contract basis will not have their contracts renewed at the end of March. A 30-day consultation period on redundancy has begun with employees.
Abbott's vascular facility in Clonmel currently employs more than 1,400 people. The company is a global healthcare company and employs approximately 70,000 people.
It has eight manufacturing sites with commercial operations in Dublin and Westport and makes diabetes products in Donegal, nutrition in Cootehill and Sligo, diagnostics in Longford and Sligo and vascular devices in Clonmel.
Jobs Minister Richard Bruton said that it was a "really tough day" for workers at Abbott in Clonmel. He said he had spoken to the company and was assured it remains committed to retaining and developing the site.
Phil Prendergast, Clonmel-based Labour MEP for Munster, said it was very distressing news for the workforce, their families and the wider community.
"The company must give all workers in that situation the full picture in terms of its intentions and their entitlements as soon as possible," she added.