Revellers in Cork have been warned against taking recreational drugs after the deaths of two friends.
Michael Coleman and Liam Coffey were found dead in a downstairs room of a rented house in Kinsale, Co Cork, on Sunday morning.
Gardai are awaiting toxicology results but believe a cocktail of drugs which formed a brown powder may have been a factor in their tragic deaths.
The Health Service Executive (HSE) has taken the unusual step of warning drug users against taking the substance, which is known to contain Methylamphetamine (MDMA Ecstasy) and Paramethoxymethamphetamine (PMMA).
Health professionals in the region and community and voluntary groups who work with users have also been urged to be vigilant in relation to the substance.
Elsewhere a man in his 20s is being questioned on suspicion of the sale and supply of drugs by detectives investigating the deaths. He is being detained at Bandon Garda Station under Section 4 of the Criminal Justice Act 1984, where he can be held for up to 24 hours.
Two other men and a woman arrested in relation to the investigation were released on Monday. Files are being prepared for the director of Public Prosecutions.
David Lane, HSE South Addiction Services, said practical steps drug users can take to prevent overdose include knowing your tolerance, avoid mixing drink and drugs, and recognise that medications prescribed by a doctor may interact with street drugs and cause an overdose.
He said: "If someone gets into difficulty after consuming a substance it is critically important to get help immediately by calling the emergency services. Symptoms associated with the above substance include high fever, rapid heart rate and agitation.
Mr Coleman, 22, from Dungarvan, recently moved to the Kinsale area with his girlfriend, a trainee teacher, and had started a job at Eli Lillis pharmaceuticals. He will be buried on Wednesday after his funeral mass at St Augustine's Church in Abbeyside. Mr Coffey, 22, from Cappoquin, was visiting the couple.