More than 120 jobs will be created at five different firms across Ireland.
Jobs Minister Richard Bruton said the businesses are fast-growing, emerging companies in Letterkenny, Dublin, and Limerick.
He said: "These companies will establish deep roots here from early in their growth and make a substantial impact on our economy. There is also of course the possibility that one of these companies will turn into a world-leading company of the future."
The jobs will be created by the following companies: Consero, which creates industry-specific events for senior-level executives, will establish its European headquarters in Dublin with 20 jobs over three years.
ExtenSys Inc, an information technology company providing internet traffic management solutions, will employ 25 people at its sales and technical support office in Limerick.
KeyedIn Solutions, which delivers cloud-based technology, plans to house its European software development, sales, marketing and technical support centre in Letterkenny, Co Donegal, with the creation of 20 jobs.
DITA Inc, global leader in optical designs, will hire 10 people when it expands its EMEA headquarters and distribution centre in Dublin.
And ZenDesk, a web-based customer support software, is to establish its finance and development centre in Dublin, with the creation of 30 jobs over the next two years.
Paul Mandell, of Consero, said: "We are excited to launch in Ireland, which offers all of the requisite components for start-up success, such as the availability of a highly skilled talent pool, a pro-business environment and the presence of a number of multinationals that will assist us to grow our European business from Ireland."
Elsewhere Barry O'Leary, of IDA Ireland, said a huge number of executives from emerging companies are visiting Ireland this week for the F.ounders conference. He said: "The five companies in today's announcement will benefit from access to a highly-skilled labour pool as well as a top class communications infrastructure - amongst other things."