Up to 80 jobs will be created over the next year at Slainte Healthcare.
The firm, which is part funded by Enterprise Ireland, provi des software solutions to healthcare facilities in a bid to improve patient care and cut costs.
The jobs announcement was made by Enterprise Minister Richard Bruton and Health Minister James Reilly as they called for other firms to come forward with ideas and products that will benefit patients.
Mr Bruton said Slainte Healthcare was one of the six companies involved in the Health Innovation Hub (HIH), a joint initiative by the two departments.
He maintained the Government's plan is for all departments and dozens of agencies to join forces to create jobs.
"Through this hub, healthcare companies can gain access to the health system to trial their products and services, honing and improving them in response to real-life demands," said the minister.
"The health system, in turn, benefits by gaining access to cutting edge products and services to solve real problems it faces."
HIH was established under the Action Plan for Jobs to support the development and advancement of healthcare innovation in Ireland.
Slainte Healthcare was among the first tranche of projects selected. Founded in 2006 by chief executive Andrew Murphy, it is now one of the fastest growing, profitable healthcare technology companies in the UK and Ireland.
Other firms in the first call for projects were Abtran, Arann Healthcare, Helix Health, Radisens Diagnostics and Rigney Dolphin.
The ministers made a second call for applications from companies who have the potential to address healthcare sector needs, particularly in infection control and hygiene management.
Mr Reilly said the hub was a unique opportunity for enterprise and for the health system.
"This initiative has great potential to benefit both innovative Irish companies and the wider health system," he added.
"More importantly, it holds the potential to improve how we manage and treat patients.
"Advan ces in technology and methods of working and how we harness these will help us keep people healthy, and keep them where they want to be - with family, and at home."
Closing date for applications is January 17.