Taoiseach Enda Kenny will hold talks with the German chancellor for the first time since they caused chaos and confusion over a bank deal on legacy debt.
Mr Kenny's discussions with Angela Merkel in Berlin are likely to re-examine easing the burden of rescuing lenders.
A Government spokesman said the trip is part of the Taoiseach's continuing engagement with European leaders in the run-up to Ireland's EU presidency, which starts in January.
He said: "The discussions between the Taoiseach and the chancellor are expected to address the Government's priorities for the Irish presidency, progress in relation to the Irish financial programme, bilateral relations between the two countries and European developments including challenges in the eurozone."
Elsewhere, the Taoiseach will formally launch The Gathering in Germany and meet a number of Irish and German companies with a view to enhancing trade and investment links.
The Taoiseach and the chancellor appeared on a collision course last month over whether a deal for Ireland would cover legacy debt.
Mr Kenny left a summit in Brussels stating that European Union leaders had given a clear reaffirmation on a decision to reduce the debt.
But within hours, Mrs Merkel claimed there would be no back-dated recapitalisation of eurozone banks.
After a frantic weekend phone call, Mr Kenny and Mrs Merkel later issued a joint statement saying the unique circumstances of Ireland's economic crisis required a special approach.