Gardai have appealed for witnesses to the incident on the Dunshaughlin to Dunboyne road (R147) in Co Meath, which happened at 12.30am.
A 21-year-old man died and three men and two women who were also in the car were injured.
Gardai said their injuries are not believed to be life-threatening.
Morning rush-hour drivers have been warned that the road is currently closed for a forensic examination and diversions are in place.
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