State broadcaster RTE has announced plans to cut its workforce by up to 60 people.
Management and union officials are in talks over the job losses, which the company hopes will be achieved through a voluntary redundancy and early retirement scheme.
Meanwhile 280 jobs have been saved at the Pfizer manufacturing facility in Dun Laoghaire, Co Dublin, after it was purchased by the world's largest biotechnology company Amgen.
The deal, which is expected to be finalised by the summer, will result in 240 workers being transferred to Amgen and 40 remaining with Pfizer.
Madhu Balachandran, senior vice president at Amgen Manufacturing, revealed that as the firm expands internationally, the Dublin site will help deliver a growing supply of its medicines for patients worldwide.
"We are impressed with the technical expertise and commitment to excellence demonstrated by the employees who work at the Dun Laoghaire site and look forward to welcoming them to Amgen's global manufacturing team," he added.
"We are grateful to the Irish Government and IDA Ireland for their support in helping us secure this world-class facility and look forward to a strong, productive relationship in the years ahead."
Local TD, Tanaiste Eamon Gilmore, said the retention of the jobs and the prospect of further growth by Amgen ends a period of uncertainty for management and staff.
"It is particularly gratifying to welcome a company of the calibre of Amgen to Dun Laoghaire in this, the new Government's first week in office," said Mr Gilmore.
"This announcement is proof that Ireland continues to be a highly attractive location for foreign direct investment."