Health Minister James Reilly faces political exile after Opposition parties announced plans to table a motion of no confidence in him.
Fianna Fail and Sinn Fein both criticised the minister's controversial proposals to slash 130 million euro from services.
Elsewhere, Labour councillor Paul O'Shea, who resigned from Ennis Town Council over the weekend because of the cuts, warned of further resignations from the party if Cabinet approves the measures.
Several TDs with the coalition also hit out at the minister's proposals to scale back frontline services.
Fianna Fail health spokesman Billy Kelleher accused the minister of targeting the most vulnerable.
He claimed there has been disappointment, disruption, dysfunction and chaos since Dr Reilly took over responsibility in the Department of Health.
"I would call on him to live up to the promise he made before the election, when he said that the day he withdrew services with nothing in their place he would walk away," said Mr Kelleher. "If he refuses to go, my party will be tabling a motion of no confidence in the minister immediately upon the resumption of the Dail."
Home help and home care, agency work and overtime will be among the worst hit in the string of cuts, which could see older people and the disabled hit particularly hard. There will also be 50,000 fewer medical card holders.
Dr Reilly has also said savings could not be properly addressed without looking at Croke Park, the 2009 agreement which guaranteed public-sector reform in return for core pay being protected.
Caoimhghin O Caolain, Sinn Fein health spokesperson, claimed Dr Reilly was plunging the health services into deep crisis. He said that Dr Reilly made great play of his changes to the Health Service Executive (HSE), claiming that they will mean more direct responsibility and management by the minister.