Three time Man Booker nominee Colm Toibin is Ireland's only hope of winning the prestigious literary prize.
The author is one of six writers on the shortlist after fellow Irish novelists Colum McCann, for TransAtlantic, and debut author Donal Ryan, for The Spinning Heart, failed to make the final cut.
Jimmy Deenihan, Minister for Arts, Heritage and the Gaeltacht, congratulated Toibin for his work The Testament of Mary which features the mother of Jesus mourning angrily years after her son's crucifixion.
"The shortlist is again eloquent in its testimony to the enduring strength and quality of Irish writing," the minister said.
"Our writers continue to be pre-eminent globally in their field and universally popular. Indeed, in a changing world, quality Irish writing is a constant. I wish those on the shortlist every success in the final selection."
The shortlist includes the favourite for the £50,000 prize, British author Jim Crace. He has been nominated for what will be his last book , Harvest, the story of a village which comes under threat.
Other nominees are Eleanor Catton (The Luminaries), Jhumpa Lahiri (The Lowland), NoViolet Bulawayo (We Need New Names) and Ruth Ozeki (A Tale For The Time Being).
Toibin was previously shortlisted in 1999 with The Blackwater Lightship and in 2004 with The Master.
Previous Irish Booker winners include Anne Enright for The Gathering in 2007; John Banville for The Sea in 2005; and Roddy Doyle for Paddy Clarke Ha Ha Ha in 1993.