Working-class Dublin joined defiant Donegal in their rejection of the European fiscal deal.
Out of Ireland's 43 constituencies, only three in the capital and two in the far north-west returned an overall No vote.
While the Government parties attempted to play down the pockets of dissent as traditionally hostile to European treaties, both Fine Gael and Labour admit they will have to reach out to them.
Junior finance minister Brian Hayes, a Fine Gael TD, bristled at the suggestion he failed to deliver a Yes in his own electoral backyard Dublin South West. "I think that's over-egging the pudding," he insisted.
"This is a national vote where everyone has the same vote. It is not determined on constituency. Our vote is no different to the vote that occurred in other parts of working-class Dublin or working-class Cork."
Almost 51% rejected the fiscal compact in Dublin South West, a constituency ravaged more than most by job losses since the economic crash.
Mr Hayes accepted some would see the result as a reflection of his own campaign, and that of his fellow constituency TD, the Communications Minister and former Labour leader Pat Rabbitte.
But he pointed to the high-profile redundancies and a traditional mistrust of increased European power among voters. "Were it not for the effort that went in by Fine Gael and Labour in the constituency, I suspect the Yes vote would be much smaller," he said.
"I'm delighted we got so many Yes votes. I would have taken your arm off at the start of the campaign if someone had said we could get 49%."
Mr Hayes said the Government would use its renewed mandate mostly to battle for further concessions on an agreement tying taxpayers to the debts of the doomed Anglo Irish Bank. "There is a lot of unfinished business," he said. "We have made progress on that but much more progress needs to happen."