Experts fear that major events such as the Olympics and Queen's Diamond Jubilee will lead to a drop in blood donations.
NHS Blood and Transplant warned that a "perfect storm" could be created in 2012 by special events, extra bank holidays and a bumper sporting calendar.
Jon Latham, assistant director for blood donation at NHS Blood and Transplant, said: "We're calling on the public to make regular blood donation a New Year's resolution. Please book your appointment and help save lives in 2012."
Singer Sophie Ellis-Bextor added: "NHS Blood and Transplant needs 230,000 new blood donors every year. I gave blood for the first time this year and plan on becoming a regular donor."
Anyone interested in donating can visit www.blood.co.uk.