A team of midwives will deliver Channel 4's alternative to the Queen's Christmas Day broadcast.
The women from the Princess Anne Hospital in Southampton are following in the footsteps of Ali G, Jamie Oliver and President Mahmoud Ahmadinejad of Iran.
The midwives, who featured in the channel's documentary series One Born Every Minute, describe the festive season at the hospital in their message.
Midwife Kay Duggan said: "It's lovely to work here at Christmas, because you meet all sorts of different people, different religions and cultures - all celebrating Christmas in their own way."
Head of Midwifery Maria Dore said she wanted people to think about families who had lost loved ones and said a birth was "a way of celebrating again".
The alternative message, which will be broadcast at 3pm, is part of a series called One Born At Christmas, which runs over the holiday period.
Channel 4 has been delivering its own Christmas message since 1993.
Last year, acid attack survivor Katie Piper urged viewers to "appreciate the beautiful things and the beautiful people that you have in your life now".
But other choices have been more controversial, including President Ahmadinejad, who delivered his 2008 broadcast to a wave of criticism.