Stephen Sutton, the inspirational cancer charity fund-raiser, has died peacefully in his sleep this morning.
His mother released a statement on the Stephen's Story Facebook page confirming his death, where she said her heart is "bursting with pride".
The 19-year-old was readmitted to hospital after developing breathing difficulties on Sunday. His family took over his Facebook account on Monday and confirmed Stephen's condition had deteriorated "due to a re-growth of tumours".
The statement read: "My heart is bursting with pride but breaking with pain for my courageous, selfless, inspirational son who passed away peacefully in his sleep in the early hours of this morning, Wednesday 14th May.
"The ongoing support and outpouring of love for Stephen will help greatly at this difficult time, in the same way as it helped Stephen throughout his journey. We all know he will never be forgotten, his spirit will live on, in all that he achieved and shared with so many."
Stephen made headlines for raising over £3million for The Teenage Cancer Trust charity, after he posted an emotional farewell message to the followers of his Stephen’s Story Facebook page. He had initially set out to raise just £10,000.
Soon, celebrities including Benedict Cumberbatch and Jason Mannford had taken to social media and encouraged people to donate to the cause.
In April, Stephen had posted a heartbreaking “final thumbs up” picture on Facebook as he feared his life was coming to an end.
But over the next seven days, his health appeared to have taken a turn for the better, and he was briefly allowed to return to his home in Burntwood, Staffordshire.
He was first diagnosed with bowel cancer aged 15, and was told in December 2012 that his condition was incurable.
Tributes for the teenager have been flooding in on Twitter, with many paying homage to his “spirit” and “bravery”.
In a statement after news of Stephen's death was announced, the Teenage Cancer Trust said: "We are humbled and hugely grateful for what Stephen achieved and continues to achieve for us.
"The thoughts of everyone here at Teenage Cancer Trust are with Stephen's family and friends."
Comedian Ricky Gervais tweeted: "RIP Stephen Sutton. A true hero & inspiration to us all."
Britain's Got Talent judge, Simon Cowell also posted: "Sadly Stephen Sutton passed away this morning.Stephen's mum "My heart is bursting with pride but breaking with pain"